| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MUC20 |
| Gene ID: | 200958 |
| Uniprot ID: | MUC20_HUMAN |
| Immunogen Region: | 100-200 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human MUC20 (NP_689886.3). |
| Immunogen Sequence: | PNFMVLIATSVETSAASGSP EGAGMTTVQTITGSDPEEAI FDTLCTDDSSEEAKTLTMDI LTLAHTSTEAKGLSSESSAS SDGPHPVITPSRASESSASS D |
| Tissue Specificity | Highly expressed in kidney, moderately in placenta, lung, prostate, liver, and digestive system. In the kidney, localized in the proximal tubules but not in the glomerulus or distal tubules. Detected in most of the male urogenital tract epithelia, with the exception of epididymis. |
| Function | May regulate MET signaling cascade. Seems to decrease hepatocyte growth factor (HGF)-induced transient MAPK activation. Blocks GRB2 recruitment to MET thus suppressing the GRB2-RAS pathway. Inhibits HGF-induced proliferation of MMP1 and MMP9 expression. |
| Protein Name | Mucin-20Muc-20 |
| Database Links | Reactome: R-HSA-5083625Reactome: R-HSA-5083632Reactome: R-HSA-5083636Reactome: R-HSA-5621480Reactome: R-HSA-8851805Reactome: R-HSA-913709Reactome: R-HSA-977068 |
| Cellular Localisation | SecretedApical Cell MembraneBasolateral Cell MembraneCell ProjectionMicrovillus Membrane |
| Alternative Antibody Names | Anti-Mucin-20 antibodyAnti-Muc-20 antibodyAnti-MUC20 antibodyAnti-KIAA1359 antibodyAnti-UNQ2782 antibodyAnti-PRO7170 antibody |
Information sourced from Uniprot.org