![Anti-MUC16/CA125 nanobody [SAA1355] (STJN000289)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200902/413084/STJN000289-SDS-PAGE-1__46329.1749232588.jpg?c=1 "Anti-MUC16/CA125 nanobody [SAA1355] (STJN000289)")
![Anti-MUC16/CA125 nanobody [SAA1355] (STJN000289)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200902/413084/STJN000289-SDS-PAGE-1__46329.1749232588.jpg?c=1 "Anti-MUC16/CA125 nanobody [SAA1355] (STJN000289)")
Anti-MUC16/CA125 nanobody [SAA1355] (STJN000289)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Mucin-16 is suitable for use in ELISA and SPR research applications. |
| Applications | ELISA/SPR |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1355 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | MUC16 |
| Gene ID | 94025 |
| Uniprot ID | MUC16_HUMAN |
Additional Info
| Post Translational Modifications | Heavily O-glycosylated.expresses both type 1 and type 2 core glycans. Heavily N-glycosylated.expresses primarily high mannose and complex bisecting type N-linked glycans. May be phosphorylated. Phosphorylation of the intracellular C-terminal domain may induce proteolytic cleavage and the liberation of the extracellular domain into the extracellular space. May contain numerous disulfide bridges. Association of several molecules of the secreted form may occur through interchain disulfide bridges providing an extraordinarily large gel-like matrix in the extracellular space or in the lumen of secretory ducts. |
| Function | Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. |
| Protein Name | Mucin-16Muc-16Ovarian Cancer-Related Tumor Marker Ca125Ca-125Ovarian Carcinoma Antigen Ca125 |
| Database Links | Reactome: R-HSA-5083625Reactome: R-HSA-5083632Reactome: R-HSA-5083636Reactome: R-HSA-5621480Reactome: R-HSA-913709Reactome: R-HSA-977068 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSecretedExtracellular SpaceMay Be Liberated Into The Extracellular Space Following The Phosphorylation Of The Intracellular C-Terminus Which Induces The Proteolytic Cleavage And Liberation Of The Extracellular Domain |
| Alternative Nanobody Names | Anti-Mucin-16 nanobodyAnti-Muc-16 nanobodyAnti-Ovarian Cancer-Related Tumor Marker Ca125 nanobodyAnti-Ca-125 nanobodyAnti-Ovarian Carcinoma Antigen Ca125 nanobodyAnti-MUC16 nanobodyAnti-CA125 nanobody |
Information sourced from Uniprot.org