| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MTRR (50-230) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MTRR |
| Gene ID: |
4552 |
| Uniprot ID: |
MTRR_HUMAN |
| Immunogen Region: |
50-230 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 50-230 of human MTRR (NP_002445.2). |
| Immunogen Sequence: |
TAPLVVVVSTTGTGDPPDTA RKFVKEIQNQTLPVDFFAHL RYGLLGLGDSEYTYFCNGGK IIDKRLQELGARHFYDTGHA DDCVGLELVVEPWIAGLWPA LRKHFRSSRGQEEISGALPV ASPASSRTDLVKSELLHIES QVELLRFDDSGRKDSEVLKQ NAVNSNQSNVVIEDFESSLT R |
| Tissue Specificity | Found in all tissues tested, particularly abundant in skeletal muscle. |
| Function | Key enzyme in methionine and folate homeostasis responsible for the reactivation of methionine synthase (MTR/MS) activity by catalyzing the reductive methylation of MTR-bound cob(II)alamin. Cobalamin (vitamin B12) forms a complex with MTR to serve as an intermediary in methyl transfer reactions that cycles between MTR-bound methylcob(III)alamin and MTR bound-cob(I)alamin forms, and occasional oxidative escape of the cob(I)alamin intermediate during the catalytic cycle leads to the inactive cob(II)alamin species (Probable). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. Also necessary for the utilization of methyl groups from the folate cycle, thereby affecting transgenerational epigenetic inheritance. Also acts as a molecular chaperone for methionine synthase by stabilizing apoMTR and incorporating methylcob(III)alamin into apoMTR to form the holoenzyme. Also serves as an aquacob(III)alamin reductase by reducing aquacob(III)alamin to cob(II)alamin.this reduction leads to stimulation of the conversion of apoMTR and aquacob(III)alamin to MTR holoenzyme. |
| Protein Name | Methionine Synthase ReductaseMsrAquacobalamin ReductaseAqcbl Reductase |
| Database Links | Reactome: R-HSA-156581Reactome: R-HSA-1614635Reactome: R-HSA-3359467Reactome: R-HSA-3359469Reactome: R-HSA-9759218 |
| Cellular Localisation | Isoform B: CytoplasmIsoform A: Cytoplasm |
| Alternative Antibody Names | Anti-Methionine Synthase Reductase antibodyAnti-Msr antibodyAnti-Aquacobalamin Reductase antibodyAnti-Aqcbl Reductase antibodyAnti-MTRR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
