| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Human/Mouse/Rat/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-MTR (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.IHC: In paraffin embedded Human Adrenal Gland shows cytoplasm staining in the cortex. Recommended concentration: 3-5µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | MTR |
| Gene ID: | 4548 |
| Uniprot ID: | METH_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_000245.2[ NP_001278868.1; NP_001278869.1 |
| Immunogen Sequence: | VEKWLGPILGYDTD |
| Function | Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. |
| Protein Name | Methionine SynthaseMs5-Methyltetrahydrofolate--Homocysteine MethyltransferaseCobalamin-Dependent Methionine SynthaseVitamin-B12 Dependent Methionine Synthase |
| Database Links | Reactome: R-HSA-156581Reactome: R-HSA-1614635Reactome: R-HSA-3359467Reactome: R-HSA-3359469Reactome: R-HSA-9013407Reactome: R-HSA-9759218 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Methionine Synthase antibodyAnti-Ms antibodyAnti-5-Methyltetrahydrofolate--Homocysteine Methyltransferase antibodyAnti-Cobalamin-Dependent Methionine Synthase antibodyAnti-Vitamin-B12 Dependent Methionine Synthase antibodyAnti-MTR antibody |
Information sourced from Uniprot.org
