| Function | Lipid phosphatase that specifically dephosphorylates the D-3 position of phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate, generating phosphatidylinositol and phosphatidylinositol 5-phosphate. Binds with high affinity to phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) but also to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), and phosphatidylinositol 5-phosphate (PtdIns(5)P), phosphatidic acid and phosphatidylserine. Negatively regulates ER-Golgi protein transport. Probably in association with MTMR9, plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3-phosphate in membrane ruffles. Acts as a negative regulator of KCNN4/KCa3.1 channel activity in CD4(+) T-cells possibly by decreasing intracellular levels of phosphatidylinositol 3-phosphate. Negatively regulates proliferation of reactivated CD4(+) T-cells. In complex with MTMR9, negatively regulates DNA damage-induced apoptosis. The formation of the MTMR6-MTMR9 complex stabilizes both MTMR6 and MTMR9 protein levels. |
| Protein Name | Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr6Myotubularin-Related Protein 6Phosphatidylinositol-3-Phosphate Phosphatase |
| Database Links | Reactome: R-HSA-1660499 |
| Cellular Localisation | CytoplasmEndoplasmic Reticulum-Golgi Intermediate CompartmentEndoplasmic ReticulumCell ProjectionRuffle MembranePeripheral Membrane ProteinCytoplasmic SidePerinuclear RegionLocalizes To Ruffles During Egf-Induced MacropinocytosisColocalizes With Mtmr9 To The Perinuclear RegionPartially Localizes To The Endoplasmic ReticulumCo-Localizes With Rab1b To The Endoplasmic Reticulum-Golgi Intermediate Compartment And To The Peri-Golgi Region |
| Alternative Antibody Names | Anti-Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase Mtmr6 antibodyAnti-Myotubularin-Related Protein 6 antibodyAnti-Phosphatidylinositol-3-Phosphate Phosphatase antibodyAnti-MTMR6 antibody |
Information sourced from Uniprot.org
