| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-MTM1 (484-603) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MTM1 |
| Gene ID: |
4534 |
| Uniprot ID: |
MTM1_HUMAN |
| Immunogen Region: |
484-603 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 484-603 of human MTM1 (NP_000243.1). |
| Immunogen Sequence: |
SARERQKVTERTVSLWSLIN SNKEKFKNPFYTKEINRVLY PVASMRHLELWVNYYIRWNP RIKQQQPNPVEQRYMELLAL RDEYIKRLEELQLANSAKLS DPPTSPSSPSQMMPHVQTHF |
| Function | Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels. |
| Protein Name | MyotubularinPhosphatidylinositol-3 -5-Bisphosphate 3-PhosphatasePhosphatidylinositol-3-Phosphate Phosphatase |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-1660516Reactome: R-HSA-1660517 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCell ProjectionFilopodiumRuffleLate EndosomeMyofibrilSarcomereLocalizes As A Dense Cytoplasmic NetworkAlso Localizes To The Plasma MembraneIncluding Plasma Membrane Extensions Such As Filopodia And RufflesPredominantly Located In The Cytoplasm Following Interaction With Mtmr12Recruited To The Late Endosome Following Egf StimulationIn Skeletal MusclesCo-Localizes With Mtmr12 In The Sarcomere |
| Alternative Antibody Names | Anti-Myotubularin antibodyAnti-Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase antibodyAnti-Phosphatidylinositol-3-Phosphate Phosphatase antibodyAnti-MTM1 antibodyAnti-CG2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
