| Function | Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis. In skeletal muscles, stabilizes MTMR12 protein levels. |
| Protein Name | MyotubularinPhosphatidylinositol-3 -5-Bisphosphate 3-PhosphatasePhosphatidylinositol-3-Phosphate Phosphatase |
| Database Links | Reactome: R-HSA-1660499Reactome: R-HSA-1660516Reactome: R-HSA-1660517 |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinCell ProjectionFilopodiumRuffleLate EndosomeMyofibrilSarcomereLocalizes As A Dense Cytoplasmic NetworkAlso Localizes To The Plasma MembraneIncluding Plasma Membrane Extensions Such As Filopodia And RufflesPredominantly Located In The Cytoplasm Following Interaction With Mtmr12Recruited To The Late Endosome Following Egf StimulationIn Skeletal MusclesCo-Localizes With Mtmr12 In The Sarcomere |
| Alternative Antibody Names | Anti-Myotubularin antibodyAnti-Phosphatidylinositol-3 -5-Bisphosphate 3-Phosphatase antibodyAnti-Phosphatidylinositol-3-Phosphate Phosphatase antibodyAnti-MTM1 antibodyAnti-CG2 antibody |
Information sourced from Uniprot.org
