Anti-MTA3 antibody (40-330) (STJ24626)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MTA3 (40-330) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MTA3 |
| Gene ID | 57504 |
| Uniprot ID | MTA3_HUMAN |
| Immunogen Region | 40-330 |
| Immunogen Sequence | AKVVCFYRRRDISNTLIMLA DKHAKEIEEESETTVEADLT DKQKHQLKHRELFLSRQYES LPATHIRGKCSVALLNETES VLSYLDKEDTFFYSLVYDPS LKTLLADKGEIRVGPRYQAD IPEMLLEGESDEREQSKLEV KVWDPNSPLTDRQIDQFLVV ARAVGTFARALDCSSSVRQP SLHMSAAAASRDITLFHAMD TLYRHSYDLSSAISVLVPLG GPVLCRDEMEEWSASEASL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 40-330 of human MTA3 (NP_065795.1). |
Additional Info
| Tissue Specificity | Expressed in germinal centers of lymphoid tissues. No expression in nonepithelial cells. |
| Function | Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6. |
| Protein Name | Metastasis-Associated Protein Mta3 |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427389Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-9679191Reactome: R-HSA-9843940Reactome: R-HSA-9844594Reactome: R-HSA-9845323 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Metastasis-Associated Protein Mta3 antibodyAnti-MTA3 antibodyAnti-KIAA1266 antibody |
Information sourced from Uniprot.org