| Host: | Rat |
| Applications: | ICC/IHC-F/WB/FC |
| Reactivity: | Human/Mouse/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rat monoclonal antibody anti-MRP4 is suitable for use in Immunocytochemistry, Immunohistochemistry, Western Blot and Flow Cytometry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | M4I-80 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a |
| Formulation: | cell culture supernatant with 0.7% BSA and 0.1% sodium azide |
| Concentration: | 200 ug/mL |
| Dilution Range: | ICC IHC-F 1:20 WB 1:50 FC |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Gene Symbol: | ABCC4 |
| Gene ID: | 10257 |
| Uniprot ID: | MRP4_HUMAN |
| Immunogen: | MRP4 aa 372-431 |
| Tissue Specificity | Widely expressed, with particularly high levels in prostate, but is barely detectable in liver. sinusoidal membrane of hepatocytes. |
| Post Translational Modifications | N-glycosylated.leading to substrate-selective effects on its transport activity. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 4 Mrp/Cmoat-Related Abc Transporter Multi-Specific Organic Anion Transporter B Moat-B Multidrug Resistance-Associated Protein 4 |
| Database Links | Reactome: R-HSA-114608 Reactome: R-HSA-382556 Reactome: R-HSA-9748787 Reactome: R-HSA-9753281 |
| Cellular Localisation | Basolateral Cell Membrane Multi-Pass Membrane Protein Apical Cell Membrane Its Localization To The Basolateral Or Apical Membranes Is Tissue-Dependent |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 4 antibody Anti-Mrp/Cmoat-Related Abc Transporter antibody Anti-Multi-Specific Organic Anion Transporter B antibody Anti-Moat-B antibody Anti-Multidrug Resistance-Associated Protein 4 antibody Anti-ABCC4 antibody Anti-MOATB antibody Anti-MRP4 antibody |
Information sourced from Uniprot.org