| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-MRAP2 (90-140 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | MRAP2 |
| Gene ID: | 112609 |
| Uniprot ID: | MRAP2_HUMAN |
| Immunogen Region: | 90-140 aa |
| Specificity: | Specific for MRAP2. |
| Immunogen: | A synthetic peptide from aa region 90-140 of human MRAP2 conjugated to blue carrier protein was used as the antigen. The peptide shares 92% identity with mouse and rat sequences. |
| Function | Modulator of melanocortin receptor 4 (MC4R), a receptor involved in energy homeostasis. Plays a central role in the control of energy homeostasis and body weight regulation by increasing ligand-sensitivity of MC4R and MC4R-mediated generation of cAMP. May also act as a negative regulator of MC2R: competes with MRAP for binding to MC2R and impairs the binding of corticotropin (ACTH) to MC2R. May also regulate activity of other melanocortin receptors (MC1R, MC3R and MC5R).however, additional evidence is required in vivo. |
| Protein Name | Melanocortin-2 Receptor Accessory Protein 2 Mc2r Accessory Protein 2 |
| Cellular Localisation | Cell Membrane Single-Pass Membrane Protein Endoplasmic Reticulum Membrane The Formation Of Antiparallel Homo- And Heterodimers Suggest That N- And C-Terminus Can Both Localize In The Cytoplasmic And Extracellular Parts Depending On The Context |
| Alternative Antibody Names | Anti-Melanocortin-2 Receptor Accessory Protein 2 antibody Anti-Mc2r Accessory Protein 2 antibody Anti-MRAP2 antibody Anti-C6orf117 antibody |
Information sourced from Uniprot.org