| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Mpo |
| Gene ID: | 17523 |
| Uniprot ID: | PERM_MOUSE |
| Immunogen Region: | 16-718 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 16-718 of mouse Mpo (NP_034954.2). |
| Immunogen Sequence: | MLQTSNGATPALLGEVENSV VLSCMEEAKQLVDRAYKERR ESIKRSLQSGSASPTELLFY FKQPVAGTRTAVRAADYLHV ALDLLKRKLQPLWPRPFNVT DVLTPAQLNLLSVSSGCAYQ DVRVTCPPNDKYRTITGHCN NRRSPTLGASNRAFVRWLPA EYEDGVSMPFGWTPGVNRNG FKVPLARQVSNAIVRFPNDQ LTKDQERALMFMQWGQFLDH DITLTPEPATRFSFFTGLN |
| Function | Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. Mediates the proteolytic cleavage of alpha-1-microglobulin to form t-alpha-1-microglobulin, which potently inhibits oxidation of low density lipoprotein particles and limits vascular damage. |
| Protein Name | MyeloperoxidaseMpo Cleaved Into - Myeloperoxidase Light Chain - Myeloperoxidase Heavy Chain |
| Database Links | Reactome: R-MMU-6798695Reactome: -MMU-8941413 |
| Cellular Localisation | Lysosome |
| Alternative Antibody Names | Anti-Myeloperoxidase antibodyAnti-Mpo Cleaved Into - Myeloperoxidase Light Chain - Myeloperoxidase Heavy Chain antibodyAnti-Mpo antibody |
Information sourced from Uniprot.org