• Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:100
  • Western blot analysis of MCF7 cells using CD110 Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Anti-MPL antibody (321-370 aa) (STJ96834)

SKU:
STJ96834

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Thrombopoietin receptor (321-370 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: MPL
Gene ID: 4352
Uniprot ID: TPOR_HUMAN
Immunogen Region: 321-370 aa
Specificity: CD110 Polyclonal Antibody detects endogenous levels of CD110 protein.
Immunogen: Synthesized peptide derived from Thrombopoietin receptor at the amino acid range 321-370
Post Translational Modifications Ubiquitination at Lys-553 and Lys-573 targets MPL for degradation by both the lysosomal and proteasomal pathways. The E3 ubiquitin-protein ligase CBL significantly contributes to this ubiquitination.
Function Receptor for thrombopoietin that acts as a primary regulator of megakaryopoiesis and platelet production. May represent a regulatory molecule specific for TPO-R-dependent immune responses.
Protein Name Thrombopoietin Receptor
Tpo-R
Myeloproliferative Leukemia Protein
Proto-Oncogene C-Mpl
Cd Antigen Cd110
Database Links Reactome: R-HSA-76009
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus
Cell Surface
Alternative Antibody Names Anti-Thrombopoietin Receptor antibody
Anti-Tpo-R antibody
Anti-Myeloproliferative Leukemia Protein antibody
Anti-Proto-Oncogene C-Mpl antibody
Anti-Cd Antigen Cd110 antibody
Anti-MPL antibody
Anti-TPOR antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance