| Short Description : | Rabbit polyclonal MPDZ (1100-1380) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MPDZ |
| Gene ID: | 8777 |
| Uniprot ID: | MPDZ_HUMAN |
| Immunogen Region: | 1100-1380 |
| Immunogen Sequence: | SLGQQSGRVMALDIFSSYTG RDIPELPEREEGEGEESELQ NTAYSNWNQPRRVELWREPS KSLGISIVGGRGMGSRLSNG EVMRGIFIKHVLEDSPAGKN GTLKPGDRIVEVDGMDLRDA SHEQAVEAIRKAGNPVVFMV QSIINRPRKSPLPSLLHNLY PKYNFSSTNPFADSLQINAD KAPSQSESEPEKAPLCSVPP PPPSAFAEMGSDHTQSSASK ISQDVDKEDEFGYSWKNIR |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1100-1380 of human MPDZ (NP_003820.2). |
| Tissue Specificity | Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. |
| Function | Member of the NMDAR signaling complex that may play a role in control of AMPAR potentiation and synaptic plasticity in excitatory synapses. Promotes clustering of HT2RC at the cell surface. |
| Protein Name | Multiple Pdz Domain ProteinMulti-Pdz Domain Protein 1 |
| Database Links | |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideApical Cell MembranePostsynaptic DensityCell ProjectionDendriteCell JunctionTight JunctionSynapseSynaptosomeColocalizes With Htr2c On The Apical Membrane Of Epithelial Choroid Plexus CellsHighly Enriched In Postsynaptic Densities (Psd)Localized To Punctae On Dendrites Of Hippocampal Neurons And Colocalizes With The Synaptic Marker Dlg4Localized Mainly In The Schmidt-Lanterman Incisures Of Myelinating Schwann CellsIn The RetinaLocalizes To The Sub-Apical Region Adjacent To The Adherens Junction Complex At The Outer Limiting MembraneEnriched At The Tight Junctions Of Epithelial CellsAssociation To The Tight Junctions Depends On Cxadr |
| Alternative Antibody Names | Anti-Multiple Pdz Domain Protein antibodyAnti-Multi-Pdz Domain Protein 1 antibodyAnti-MPDZ antibodyAnti-MUPP1 antibody |
Information sourced from Uniprot.org
