| Host: | Alpaca |
| Applications: | ELISA/FCM/SPR |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Alpaca monoclonal nanobody anti-IL23R is suitable for use in ELISA, FConfocal Microscopy and SPR research applications. |
| Clonality : | Monoclonal |
| Clone ID : | SAA2269 |
| Conjugation: | Unconjugated |
| Isotype: | VHH-Fc |
| Formulation: | 0.01M PBS, pH 7.4. |
| Purification: | Protein A/G purified from cell culture supernatant. |
| Concentration: | Lot specific |
| Dilution Range: | ELISA: 1:2000-1:20000 |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin: | Please contact with the lab for this information. |
| Gene Symbol: | IL23R |
| Gene ID: | 149233 |
| Uniprot ID: | IL23R_HUMAN |
| Post Translational Modifications | Phosphorylated in response to IL23. |
| Function | Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. |
| Protein Name | Interleukin-23 ReceptorIl-23 ReceptorIl-23r |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-9020933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Nanobody Names | Anti-Interleukin-23 Receptor nanobodyAnti-Il-23 Receptor nanobodyAnti-Il-23r nanobodyAnti-IL23R nanobody |
Information sourced from Uniprot.org
![Anti-IL23R nanobody [SAA1299] (STJN000282)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/200895/413077/STJN000282-SDS-PAGE-1__80941.1749232583.jpg?c=1 "Anti-IL23R nanobody [SAA1299] (STJN000282)")