| Function | Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins. In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis. The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs. Promotes migration of primary monocytes and neutrophils, in response to various chemokines. |
| Protein Name | Motile Sperm Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-9013405 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinLocalization To Contact Sites Involving The Endoplasmic Reticulum And Several Organelles Is Regulated By Interaction With Proteins Containing Ffat MotifDynamically Distributes Between Specific Subdomains Of The Endoplasmic Reticulum (Er): Er Membranes In Contact With Lipid Droplets (Lds) And The Remainder Of The Er |
| Alternative Antibody Names | Anti-Motile Sperm Domain-Containing Protein 2 antibodyAnti-MOSPD2 antibody |
Information sourced from Uniprot.org
