| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MNS1 |
| Gene ID: | 55329 |
| Uniprot ID: | MNS1_HUMAN |
| Immunogen Region: | 366-495 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 366-495 of human MNS1 (NP_060835.1). |
| Immunogen Sequence: | QAAKEEEENFRKTMLAKFAE DDRIELMNAQKQRMKQLEHR RAVEKLIEERRQQFLADKQR ELEEWQLQQRRQGFINAIIE EERLKLLKEHATNLLGYLPK GVFKKEDDIDLLGEEFRKVY QQRSEICEEK |
| Tissue Specificity | Expressed in nasal respiratory epithelium and in the sperm. |
| Function | Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating. May play a role in the control of meiotic division and germ cell differentiation through regulation of pairing and recombination during meiosis. Required for sperm flagella assembly. May play a role in the assembly and function of the outer dynein arm-docking complex (ODA-DC). ODA-DC mediates outer dynein arms (ODA) binding onto the axonemal doublet microtubules. |
| Protein Name | Meiosis-Specific Nuclear Structural Protein 1 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonCilium AxonemeFlagellum AxonemeMicrotubule Inner Protein (Mip) Part Of The Dynein-Decorated Doublet Microtubules (Dmts) In Cilia Axoneme |
| Alternative Antibody Names | Anti-Meiosis-Specific Nuclear Structural Protein 1 antibodyAnti-MNS1 antibody |
Information sourced from Uniprot.org