Anti-MMRN1 antibody (963-1013 aa) (STJ194637)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human MMRN1 at the amino acid range 963-1013
General Information
| Short Description | Rabbit polyclonal anti-Multimerin-1 (963-1013 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MMRN1 |
| Gene ID | 22915 |
| Uniprot ID | MMRN1_HUMAN |
| Immunogen | Synthesized peptide derived from the human MMRN1 at the amino acid range 963-1013 |
| Immunogen Region | 963-1013 aa |
| Specificity | This antibody detects endogenous levels of MMRN1 at Human/Mouse |
Additional Info
| Post Translational Modifications | The N-terminus is blocked. Extensively N-glycosylated. O-fucosylated within the EMI domain (at Thr-216 and Thr-265) by FUT10/POFUT3 and FUT11/POFUT4. O-fucosylation at Thr-216 and Thr-1055 are required for facilitating protein folding and secretion. |
| Function | Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. |
| Protein Name | Multimerin-1Emilin-4Elastin Microfibril Interface Located Protein 4Elastin Microfibril Interfacer 4Endothelial Cell Multimerin Cleaved Into - Platelet Glycoprotein Ia* - 155 Kda Platelet MultimerinP-155P155 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | SecretedO-Fucosylation Of Thr-216 And Thr-1055 Is Important For Protein Secretion |
| Alternative Antibody Names | Anti-Multimerin-1 antibodyAnti-Emilin-4 antibodyAnti-Elastin Microfibril Interface Located Protein 4 antibodyAnti-Elastin Microfibril Interfacer 4 antibodyAnti-Endothelial Cell Multimerin Cleaved Into - Platelet Glycoprotein Ia* - 155 Kda Platelet Multimerin antibodyAnti-P-155 antibodyAnti-P155 antibodyAnti-MMRN1 antibodyAnti-ECM antibodyAnti-EMILIN4 antibodyAnti-GPIA* antibodyAnti-MMRN antibody |
Information sourced from Uniprot.org