Anti-MMP12 antibody (362-411) (STJ94160)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from human MMP-12. AA range:362-411
General Information
| Short Description | Rabbit polyclonal anti-Macrophage metalloelastase (362-411) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MMP12 |
| Gene ID | 4321 |
| Uniprot ID | MMP12_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from human MMP-12. AA range:362-411 |
| Immunogen Region | 362-411 |
| Specificity | MMP-12 Polyclonal Antibody detects endogenous levels of MMP-12 protein. |
Additional Info
| Tissue Specificity | Found in alveolar macrophages but not in peripheral blood monocytes. |
| Function | May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. |
| Protein Name | Macrophage MetalloelastaseMmeMacrophage ElastaseMeHmeMatrix Metalloproteinase-12Mmp-12 |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Macrophage Metalloelastase antibodyAnti-Mme antibodyAnti-Macrophage Elastase antibodyAnti-Me antibodyAnti-Hme antibodyAnti-Matrix Metalloproteinase-12 antibodyAnti-Mmp-12 antibodyAnti-MMP12 antibodyAnti-HME antibody |
Information sourced from Uniprot.org