| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S4696RM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:66000-1:264000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MMP1 |
| Gene ID: | 4312 |
| Uniprot ID: | MMP1_HUMAN |
| Immunogen Region: | 93-210 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 93-210 of human MMP1 (NP_002412.1). |
| Immunogen Sequence: | GVPDVAQFVLTEGNPRWEQT HLTYRIENYTPDLPRADVDH AIEKAFQLWSNVTPLTFTKV SEGQADIMISFVRGDHRDNS PFDGPGGNLAHAFQPGPGIG GDAHFDEDERWTNNFREY |
| Post Translational Modifications | Undergoes autolytic cleavage to two major forms (22 kDa and 27 kDa). A minor form (25 kDa) is the glycosylated form of the 22 kDa form. The 27 kDa form has no activity while the 22/25 kDa form can act as activator for collagenase. Tyrosine phosphorylated in platelets by PKDCC/VLK. |
| Function | Cleaves collagens of types I, II, and III at one site in the helical domain. Also cleaves collagens of types VII and X. In case of HIV infection, interacts and cleaves the secreted viral Tat protein, leading to a decrease in neuronal Tat's mediated neurotoxicity. |
| Protein Name | Interstitial Collagenase Fibroblast Collagenase Matrix Metalloproteinase-1 Mmp-1 Cleaved Into - 22 Kda Interstitial Collagenase - 27 Kda Interstitial Collagenase |
| Database Links | Reactome: R-HSA-1442490 Reactome: R-HSA-1474228 Reactome: R-HSA-1592389 Reactome: R-HSA-210991 Reactome: R-HSA-381426 Reactome: R-HSA-6785807 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix |
| Alternative Antibody Names | Anti-Interstitial Collagenase antibody Anti-Fibroblast Collagenase antibody Anti-Matrix Metalloproteinase-1 antibody Anti-Mmp-1 Cleaved Into - 22 Kda Interstitial Collagenase - 27 Kda Interstitial Collagenase antibody Anti-MMP1 antibody Anti-CLG antibody |
Information sourced from Uniprot.org