Anti-MMADHC antibody (STJA0008663)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human MMADHC
General Information
| Short Description | Rabbit polyclonal anti-Cobalamin trafficking protein CblD for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MMADHC |
| Gene ID | 27249 |
| Uniprot ID | MMAD_HUMAN |
| Immunogen | Synthesized peptide derived from human MMADHC |
| Specificity | This antibody detects endogenous levels of MMADHC at Human, Mouse, Rat |
Additional Info
| Function | Involved in cobalamin metabolism and trafficking. Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl). Promotes oxidation of cob(II)alamin bound to MMACHC. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine. |
| Protein Name | Cobalamin Trafficking Protein CbldCbldMethylmalonic Aciduria And Homocystinuria Type D Protein - Mitochondrial |
| Database Links | Reactome: R-HSA-3359473Reactome: R-HSA-9759218 |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Cobalamin Trafficking Protein Cbld antibodyAnti-Cbld antibodyAnti-Methylmalonic Aciduria And Homocystinuria Type D Protein - Mitochondrial antibodyAnti-MMADHC antibodyAnti-C2orf25 antibodyAnti-CL25022 antibodyAnti-HSPC161 antibodyAnti-My011 antibody |
Information sourced from Uniprot.org