![Anti-MLANA nanobody [SAA1259] (STJN000279)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200892/413074/STJN000279-SDS-PAGE-1__98295.1749232580.jpg?c=1 "Anti-MLANA nanobody [SAA1259] (STJN000279)")
![Anti-MLANA nanobody [SAA1259] (STJN000279)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200892/413074/STJN000279-SDS-PAGE-1__98295.1749232580.jpg?c=1 "Anti-MLANA nanobody [SAA1259] (STJN000279)")
Anti-MLANA nanobody [SAA1259] (STJN000279)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Melanoma antigen Recognized By T-Cells 1 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1259 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | MLANA |
| Gene ID | 2315 |
| Uniprot ID | MAR1_HUMAN |
Additional Info
| Post Translational Modifications | Acylated. |
| Function | Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. |
| Protein Name | Melanoma Antigen Recognized By T-Cells 1Mart-1Antigen Lb39-AaAntigen Sk29-AaProtein Melan-A |
| Database Links | Reactome: R-HSA-9824585 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iii Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneMelanosomeAlso Found In Small Vesicles And Tubules Dispersed Over The Entire CytoplasmA Small Fraction Of The Protein Is Inserted Into The Membrane In An Inverted OrientationInversion Of Membrane Topology Results In The Relocalization Of The Protein From A Predominant Golgi/Post-Golgi Area To The Endoplasmic ReticulumMelanoma Cells Expressing The Protein With An Inverted Membrane Topology Are More Effectively Recognized By Specific Cytolytic T-Lymphocytes Than Those Expressing The Protein In Its Native Membrane Orientation |
| Alternative Nanobody Names | Anti-Melanoma Antigen Recognized By T-Cells 1 nanobodyAnti-Mart-1 nanobodyAnti-Antigen Lb39-Aa nanobodyAnti-Antigen Sk29-Aa nanobodyAnti-Protein Melan-A nanobodyAnti-MLANA nanobodyAnti-MART1 nanobody |
Information sourced from Uniprot.org