Anti-MLANA nanobody [SAA1259] (STJN000279)

Anti-MLANA nanobody [SAA1259] (STJN000279)

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STJN000279
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Host: Alpaca
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Melanoma antigen Recognized By T-Cells 1 is suitable for use in ELISA research applications.
Clonality : Monoclonal
Clone ID : SAA1259
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: MLANA
Gene ID: 2315
Uniprot ID: MAR1_HUMAN
Post Translational Modifications Acylated.
Function Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes.
Protein Name Melanoma Antigen Recognized By T-Cells 1
Mart-1
Antigen Lb39-Aa
Antigen Sk29-Aa
Protein Melan-A
Database Links Reactome: R-HSA-9824585
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Iii Membrane Protein
Golgi Apparatus
Trans-Golgi Network Membrane
Melanosome
Also Found In Small Vesicles And Tubules Dispersed Over The Entire Cytoplasm
A Small Fraction Of The Protein Is Inserted Into The Membrane In An Inverted Orientation
Inversion Of Membrane Topology Results In The Relocalization Of The Protein From A Predominant Golgi/Post-Golgi Area To The Endoplasmic Reticulum
Melanoma Cells Expressing The Protein With An Inverted Membrane Topology Are More Effectively Recognized By Specific Cytolytic T-Lymphocytes Than Those Expressing The Protein In Its Native Membrane Orientation
Alternative Nanobody Names Anti-Melanoma Antigen Recognized By T-Cells 1 nanobody
Anti-Mart-1 nanobody
Anti-Antigen Lb39-Aa nanobody
Anti-Antigen Sk29-Aa nanobody
Anti-Protein Melan-A nanobody
Anti-MLANA nanobody
Anti-MART1 nanobody

Information sourced from Uniprot.org

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