| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-E3 ubiquitin-protein ligase makorin-1 (333-383 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MKRN1 |
| Gene ID: | 23608 |
| Uniprot ID: | MKRN1_HUMAN |
| Immunogen Region: | 333-383 aa |
| Specificity: | This antibody detects endogenous levels of MKRN1 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human MKRN1 at the amino acid range 333-383 |
| Post Translational Modifications | Auto-ubiquitinated.which leads to proteasomal degradation. |
| Function | E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include FILIP1, p53/TP53, CDKN1A and TERT. Keeps cells alive by suppressing p53/TP53 under normal conditions, but stimulates apoptosis by repressing CDKN1A under stress conditions. Acts as a negative regulator of telomerase. Has negative and positive effects on RNA polymerase II-dependent transcription. |
| Protein Name | E3 Ubiquitin-Protein Ligase Makorin-1Ring Finger Protein 61Ring-Type E3 Ubiquitin Transferase Makorin-1 |
| Database Links | Reactome: R-HSA-198323Reactome: R-HSA-8948751Reactome: R-HSA-983168 |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Makorin-1 antibodyAnti-Ring Finger Protein 61 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Makorin-1 antibodyAnti-MKRN1 antibodyAnti-RNF61 antibody |
Information sourced from Uniprot.org