| Host: |
Goat |
| Applications: |
Pep-ELISA/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-Mitofusin 1 (Internal) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:64000.IHC: Paraffin embedded Human Uterus and Adrenal Gland. Recommended concentration: 3.75µg/ml. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
MFN1 |
| Gene ID: |
55669 |
| Uniprot ID: |
MFN1_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_284941.2 |
| Immunogen Sequence: |
NKAVQLENELEN |
| Post Translational Modifications | Ubiquitinated by non-degradative ubiquitin by PRKN. Deubiquitination by USP30 inhibits mitochondrial fusion. Ubiquitinated by MARCHF5. When mitochondria are depolarized and dysfunctional, it is ubiquitinated by a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that contains FBXO7 and PRKN. |
| Function | Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Membrane clustering requires GTPase activity. It may involve a major rearrangement of the coiled coil domains. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks (in vitro). Has low GTPase activity. |
| Protein Name | Mitofusin-1Fzo HomologTransmembrane Gtpase Mfn1 |
| Database Links | Reactome: R-HSA-5205685Reactome: R-HSA-9013419Reactome: R-HSA-983231 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane ProteinIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Mitofusin-1 antibodyAnti-Fzo Homolog antibodyAnti-Transmembrane Gtpase Mfn1 antibodyAnti-MFN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
