| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Mitochondrial Mn superoxide dismutase (SOD2) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | Mixed |
| Formulation: | Lyophilized serum with 0.02% thimerosal |
| Purification: | Whole serum |
| Dilution Range: | WB 1:1000-1:4000IHC 1:50-1:100 |
| Storage Instruction: | Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. At least 12 months after purchase at 2-8°C (lyophilized formulations). After reconstitution, aliquot and store at |
| Gene Symbol: | SOD2 |
| Gene ID: | 6648 |
| Uniprot ID: | SODM_HUMAN |
| Immunogen Region: | SOD2 |
| Specificity: | Mitochondrial manganese Superoxide Dismutase (SOD2) , no cross reactivity to SOD1. |
| Immunogen: | A synthetic peptide (KHSLPDLPYDGALEPHINC) of human/rat/mouse mitochondrial manganese Superoxide Dismutase (SOD2) , conjugated to Keyhole Limpet Hemocyanin. |
| Immunogen Sequence: | Human |
| Post Translational Modifications | Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity. Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting. Polyubiquitinated.leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability. |
| Function | Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. |
| Protein Name | Superoxide Dismutase Mn - Mitochondrial |
| Database Links | Reactome: R-HSA-2151201Reactome: R-HSA-3299685Reactome: R-HSA-8862803Reactome: R-HSA-8950505Reactome: R-HSA-9615017Reactome: R-HSA-9841251 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Superoxide Dismutase Mn - Mitochondrial antibodyAnti-SOD2 antibody |
Information sourced from Uniprot.org