| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Miro1 (400-450 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | RHOT1 |
| Gene ID: | 55288 |
| Uniprot ID: | MIRO1_HUMAN |
| Immunogen Region: | 400-450 aa |
| Specificity: | Specific for MIRO1. |
| Immunogen: | A synthetic peptide from aa region 400-450 of human MIRO1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse. |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution. Promotes mitochondrial fission during high calcium conditions. |
| Protein Name | Mitochondrial Rho Gtpase 1Miro-1Hmiro-1Rac-Gtp-Binding Protein-Like ProteinRas Homolog Gene Family Member T1 |
| Database Links | Reactome: R-HSA-5689880Reactome: R-HSA-9013425 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Type Iv Membrane ProteinColocalizes With Mgarp And Rhot2 At The Mitochondria |
| Alternative Antibody Names | Anti-Mitochondrial Rho Gtpase 1 antibodyAnti-Miro-1 antibodyAnti-Hmiro-1 antibodyAnti-Rac-Gtp-Binding Protein-Like Protein antibodyAnti-Ras Homolog Gene Family Member T1 antibodyAnti-RHOT1 antibodyAnti-ARHT1 antibody |
Information sourced from Uniprot.org