| Short Description : | Rabbit polyclonal anti-E3 ubiquitin-protein ligase MIB2 for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MIB2 |
| Gene ID: | 142678 |
| Uniprot ID: | MIB2_HUMAN |
| Immunogen: | Synthesized peptide derived from part of the human protein |
| Specificity: | MIB2 Polyclonal Antibody detects endogenous levels of protein. |
| Post Translational Modifications | Ubiquitinated. Possibly via autoubiquitination. |
| Function | E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. |
| Protein Name | E3 Ubiquitin-Protein Ligase Mib2Mind Bomb Homolog 2Novel Zinc Finger ProteinNovelzinPutative Nf-Kappa-B-Activating Protein 002nRing-Type E3 Ubiquitin Transferase Mib2SkeletrophinZinc Finger Zz Type With Ankyrin Repeat Domain Protein 1 |
| Database Links | Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2691232Reactome: R-HSA-2894862Reactome: R-HSA-2979096Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-9013507Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmEndosomeColocalizes With Endosomal Compartments |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Mib2 antibodyAnti-Mind Bomb Homolog 2 antibodyAnti-Novel Zinc Finger Protein antibodyAnti-Novelzin antibodyAnti-Putative Nf-Kappa-B-Activating Protein 002n antibodyAnti-Ring-Type E3 Ubiquitin Transferase Mib2 antibodyAnti-Skeletrophin antibodyAnti-Zinc Finger Zz Type With Ankyrin Repeat Domain Protein 1 antibodyAnti-MIB2 antibodyAnti-SKD antibodyAnti-ZZANK1 antibody |
Information sourced from Uniprot.org
