| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MGLL |
| Gene ID: | 11343 |
| Uniprot ID: | MGLL_HUMAN |
| Immunogen Region: | 11-313 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 11-313 of human MGLL (NP_009214.1). |
| Immunogen Sequence: | MPEESSPRRTPQSIPYQDLP HLVNADGQYLFCRYWKPTGT PKALIFVSHGAGEHSGRYEE LARMLMGLDLLVFAHDHVGH GQSEGERMVVSDFHVFVRDV LQHVDSMQKDYPGLPVFLLG HSMGGAIAILTAAERPGHFA GMVLISPLVLANPESATTFK VLAAKVLNLVLPNLSLGPID SSVLSRNKTEVDIYNSDPLI CRAGLKVCFGIQLLNAVSRV ERALPKLTVPFLLLQGSAD |
| Tissue Specificity | Detected in adipose tissue, lung, liver, kidney, brain and heart. |
| Function | Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain. Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth. |
| Protein Name | Monoglyceride LipaseMglHu-K5Lysophospholipase HomologLysophospholipase-LikeMonoacylglycerol LipaseMagl |
| Database Links | Reactome: R-HSA-1482883Reactome: R-HSA-163560Reactome: R-HSA-426048 |
| Cellular Localisation | CytoplasmCytosolMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Monoglyceride Lipase antibodyAnti-Mgl antibodyAnti-Hu-K5 antibodyAnti-Lysophospholipase Homolog antibodyAnti-Lysophospholipase-Like antibodyAnti-Monoacylglycerol Lipase antibodyAnti-Magl antibodyAnti-MGLL antibody |
Information sourced from Uniprot.org