Anti-MGEA5/OGA antibody [SRM14721] (STJ11109451)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal MGEA5/OGA antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM14721 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB, 1:3000-1:12000IHC-P, 1:1000-1:5000ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | OGA |
| Gene ID | 10724 |
| Uniprot ID | OGA_HUMAN |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Tissue Specificity | Ubiquitous. Shows highest expression in the brain, placenta and pancreas. |
| Post Translational Modifications | Proteolytically cleaved by caspase-3 during apoptosis. The fragments interact with each other.cleavage does not decrease enzyme activity. |
| Function | Isoform 1: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, GSDMD, LMNB1 and TAB1. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity. Isoform 3: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1. |
| Protein Name | Protein O-GlcnacaseOgaBeta-N-AcetylglucosaminidaseBeta-N-AcetylhexosaminidaseBeta-HexosaminidaseMeningioma-Expressed Antigen 5N-Acetyl-Beta-D-GlucosaminidaseN-Acetyl-Beta-GlucosaminidaseNuclear Cytoplasmic O-Glcnacase And AcetyltransferaseNcoat |
| Database Links | |
| Cellular Localisation | Isoform 3: NucleusIsoform 1: Cytoplasm |
| Alternative Antibody Names | Anti-Protein O-Glcnacase antibodyAnti-Oga antibodyAnti-Beta-N-Acetylglucosaminidase antibodyAnti-Beta-N-Acetylhexosaminidase antibodyAnti-Beta-Hexosaminidase antibodyAnti-Meningioma-Expressed Antigen 5 antibodyAnti-N-Acetyl-Beta-D-Glucosaminidase antibodyAnti-N-Acetyl-Beta-Glucosaminidase antibodyAnti-Nuclear Cytoplasmic O-Glcnacase And Acetyltransferase antibodyAnti-Ncoat antibodyAnti-OGA antibodyAnti-HEXC antibodyAnti-KIAA0679 antibodyAnti-MEA5 antibodyAnti-MGEA5 antibody |
Information sourced from Uniprot.org