| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MGAM |
| Gene ID: | 8972 |
| Uniprot ID: | MGA_HUMAN |
| Immunogen Region: | 860-1090 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 860-1090 of human MGAM (NP_004659.2). |
| Immunogen Sequence: | ETKDTVANKVYLLCEFSVTQ NRLEVNISQSTYKDPNNLAF NEIKILGTEEPSNVTVKHNG VPSQTSPTVTYDSNLKVAII TDIDLLLGEAYTVEWSIKIR DEEKIDCYPDENGASAENCT ARGCIWEASNSSGVPFCYFV NDLYSVSDVQYNSHGATADI SLKSSVYANAFPSTPVNPLR LDVTYHKNEMLQFKIYDPNK NRYEVPVPLNIPSMPSSTPE GQLYDVLIKKN |
| Tissue Specificity | Broadly expressed. Highly expressed in small intestine. Expressed in granulocytes. |
| Post Translational Modifications | N- and O-glycosylated. Does not undergo intracellular or extracellular proteolytic cleavage. Sulfated. |
| Function | Alpha-(1,4) exo-glucosidase involved in breakdown of dietary starch oligosaccharides in small intestine. Cleaves the non-reducing alpha-(1,4)-linked glucose residue in linear dextrins with retention of anomeric center stereochemistry. Mainly hydrolyzes short length oligomaltoses having two to seven glucose residues. Can cleave alpha-(1,2), alpha-(1,3) and alpha-(1,6) glycosidic linkages with lower efficiency, whereas beta glycosidic linkages are usually not hydrolyzed. |
| Protein Name | Maltase-GlucoamylaseAlpha-1 -4-Glucosidase |
| Database Links | Reactome: R-HSA-189085Reactome: R-HSA-6798695 |
| Cellular Localisation | Apical Cell MembraneSingle-Pass Type Ii Membrane ProteinBrush Border |
| Alternative Antibody Names | Anti-Maltase-Glucoamylase antibodyAnti-Alpha-1 -4-Glucosidase antibodyAnti-MGAM antibodyAnti-MGA antibodyAnti-MGAML antibody |
Information sourced from Uniprot.org