• Immunohistochemistry of rat brain with Anti-MFN2 primary antibody (STJ501759) at 1:100 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-MFN2 antibody (543-593) (STJ501759)

SKU:
STJ501759-100

£441.50
Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-MFN2 (543-593) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.6 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: MFN2
Gene ID: 9927
Uniprot ID: MFN2_HUMAN
Immunogen Region: 543-593
Immunogen: Synthetic peptide taken within amino acid region 543-593 on human Mitofusin 2 protein.
Tissue Specificity Ubiquitous.expressed at low level. Highly expressed in heart and kidney.
Post Translational Modifications Phosphorylated by PINK1. Ubiquitinated by non-degradative ubiquitin by PRKN, promoting mitochondrial fusion.deubiquitination by USP30 inhibits mitochondrial fusion. Ubiquitinated by HUWE1 when dietary stearate (C18:0) levels are low.ubiquitination inhibits mitochondrial fusion.
Function Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion. Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events. Overexpression induces the formation of mitochondrial networks. Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PRKN recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.
Protein Name Mitofusin-2
Transmembrane Gtpase Mfn2
Database Links Reactome: R-HSA-5205685
Reactome: R-HSA-9013419
Reactome: R-HSA-983231
Cellular Localisation Mitochondrion Outer Membrane
Multi-Pass Membrane Protein
Colocalizes With Bax During Apoptosis
Alternative Antibody Names Anti-Mitofusin-2 antibody
Anti-Transmembrane Gtpase Mfn2 antibody
Anti-MFN2 antibody
Anti-CPRP1 antibody
Anti-KIAA0214 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance