| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human/Mouse/Rat/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-MEX3C (541-554) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 60+36kDa bands observed in Mouse Testis lysates, and these bands reduced after knock-down by gene trap (calculated MW of 69.4kDa according to NP_057710.3). Recommended concentra |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | MEX3C |
| Gene ID: | 51320 |
| Uniprot ID: | MEX3C_HUMAN |
| Immunogen Region: | 541-554 |
| Accession Number: | NP_057710.3 |
| Immunogen Sequence: | TPRLSPTFPESIEH |
| Function | E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation. |
| Protein Name | Rna-Binding E3 Ubiquitin-Protein Ligase Mex3cRing Finger And Kh Domain-Containing Protein 2Ring Finger Protein 194Ring-Type E3 Ubiquitin Transferase Mex3c |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | CytoplasmNucleusPredominantly Expressed In The Cytoplasm And Shuttles Between The Cytoplasm And The Nucleus Through The Crm1 Export PathwayMay Act As Suppressor Of Replication Stress And Chromosome Missegregation |
| Alternative Antibody Names | Anti-Rna-Binding E3 Ubiquitin-Protein Ligase Mex3c antibodyAnti-Ring Finger And Kh Domain-Containing Protein 2 antibodyAnti-Ring Finger Protein 194 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Mex3c antibodyAnti-MEX3C antibodyAnti-RKHD2 antibodyAnti-RNF194 antibodyAnti-BM-013 antibody |
Information sourced from Uniprot.org