| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | RBBP7 |
| Gene ID: | 5931 |
| Uniprot ID: | RBBP7_HUMAN |
| Specificity: | A synthetic methylated peptide around H96 of human RBBP7 (NP_002884.1). |
| Immunogen Sequence: | ASHCD |
| Function | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication.the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression.the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling.and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development.and the NURF (nucleosome remodeling factor) complex. |
| Protein Name | Histone-Binding Protein Rbbp7 Histone Acetyltransferase Type B Subunit 2 Nucleosome-Remodeling Factor Subunit Rbap46 Retinoblastoma-Binding Protein 7 Rbbp-7 Retinoblastoma-Binding Protein P46 |
| Database Links | Reactome: R-HSA-212300 Reactome: R-HSA-2559580 Reactome: R-HSA-3214815 Reactome: R-HSA-3214841 Reactome: R-HSA-3214847 Reactome: R-HSA-3214858 Reactome: R-HSA-427389 Reactome: R-HSA-5617472 Reactome: R-HSA-606279 Reactome: R-HSA-6804758 Reactome: R-HSA-73762 Reactome: R-HSA-8943724 Reactome: R-HSA-8951664 Reactome: R-HSA-8953750 Reactome: R-HSA-9609690 Reactome: R-HSA-9679191 Reactome: R-HSA-9710421 Reactome: R-HSA-9843940 Reactome: R-HSA-9844594 Reactome: R-HSA-9845323 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Histone-Binding Protein Rbbp7 antibody Anti-Histone Acetyltransferase Type B Subunit 2 antibody Anti-Nucleosome-Remodeling Factor Subunit Rbap46 antibody Anti-Retinoblastoma-Binding Protein 7 antibody Anti-Rbbp-7 antibody Anti-Retinoblastoma-Binding Protein P46 antibody Anti-RBBP7 antibody Anti-RBAP46 antibody |
Information sourced from Uniprot.org