Anti-Mesothelin antibody [DM71] (STJA0038176)

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STJA0038176-100
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Host: Rabbit
Applications: FC/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal anti-Mesothelin for use in FC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : DM71
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Purification: Affinity Chromatography
Dilution Range: FC 1:50-1:100
ELISA 1:10000
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: MSLN
Gene ID: 10232
Uniprot ID: MSLN_HUMAN
Immunogen: Recombinant human mesothelin protein
Tissue Specificity Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level).
Post Translational Modifications Both MPF and the cleaved form of mesothelin are N-glycosylated. Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin.
Function Membrane-anchored forms may play a role in cellular adhesion. Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro.
Protein Name Mesothelin
Cak1 Antigen
Pre-Pro-Megakaryocyte-Potentiating Factor Cleaved Into - Megakaryocyte-Potentiating Factor
Mpf - Mesothelin - Cleaved Form
Database Links Reactome: R-HSA-163125
Reactome: R-HSA-381426
Reactome: R-HSA-8957275
Cellular Localisation Cell Membrane
Lipid-Anchor
Gpi-Anchor
Golgi Apparatus
Megakaryocyte-Potentiating Factor: Secreted
Isoform 3: Secreted
Alternative Antibody Names Anti-Mesothelin antibody
Anti-Cak1 Antigen antibody
Anti-Pre-Pro-Megakaryocyte-Potentiating Factor Cleaved Into - Megakaryocyte-Potentiating Factor antibody
Anti-Mpf - Mesothelin - Cleaved Form antibody
Anti-MSLN antibody
Anti-MPF antibody

Information sourced from Uniprot.org

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