![Anti-Mesothelin antibody [5B2] (STJ16101763)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/152269/347117/STJ16101763_1__39990.1681999384.jpg?c=1 "Anti-Mesothelin antibody [5B2] (STJ16101763)")
![Anti-Mesothelin antibody [5B2] (STJ16101763)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/152269/347117/STJ16101763_1__39990.1681999384.jpg?c=1 "Anti-Mesothelin antibody [5B2] (STJ16101763)")
| Host: | Mouse |
| Applications: | IHC-P |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Mesothelin is suitable for use in Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 5B2 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Tissue culture supernatant with sodium azide |
| Concentration: | >=40 mg/L |
| Dilution Range: | IHC-P 1:40 |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Gene Symbol: | MSLN |
| Gene ID: | 10232 |
| Uniprot ID: | MSLN_HUMAN |
| Immunogen: | Recombinant prokaryotic fusion protein corresponding to approximately 100 amino acids which are present in the membrane-bound form of the mesothelin molecule. |
| Tissue Specificity | Expressed in lung. Expressed at low levels in heart, placenta and kidney. Expressed in mesothelial cells. Highly expressed in mesotheliomas, ovarian cancers, and some squamous cell carcinomas (at protein level). |
| Post Translational Modifications | Both MPF and the cleaved form of mesothelin are N-glycosylated. Proteolytically cleaved by a furin-like convertase to generate megakaryocyte-potentiating factor (MPF), and the cleaved form of mesothelin. |
| Function | Membrane-anchored forms may play a role in cellular adhesion. Megakaryocyte-potentiating factor (MPF) potentiates megakaryocyte colony formation in vitro. |
| Protein Name | Mesothelin Cak1 Antigen Pre-Pro-Megakaryocyte-Potentiating Factor Cleaved Into - Megakaryocyte-Potentiating Factor Mpf - Mesothelin - Cleaved Form |
| Database Links | Reactome: R-HSA-163125 Reactome: R-HSA-381426 Reactome: R-HSA-8957275 |
| Cellular Localisation | Cell Membrane Lipid-Anchor Gpi-Anchor Golgi Apparatus Megakaryocyte-Potentiating Factor: Secreted Isoform 3: Secreted |
| Alternative Antibody Names | Anti-Mesothelin antibody Anti-Cak1 Antigen antibody Anti-Pre-Pro-Megakaryocyte-Potentiating Factor Cleaved Into - Megakaryocyte-Potentiating Factor antibody Anti-Mpf - Mesothelin - Cleaved Form antibody Anti-MSLN antibody Anti-MPF antibody |
Information sourced from Uniprot.org