| Background | This antibody recognizes a molecular complex consisting of two bands with MW of 150 kD and 90 kD respectively (reduced 4 subunits 120 kD, 95 kD, 29 kD and 25 kD). The antibody reacts strongly with melanoma cells derived from cell lines and short term cultures and melanoma cells in frozen tissue sections. The antigen detected by this antibody is found to be associated with the adhesion, spreading and motility of human cultured melanoma cells. Cross reactions: The antibody reacts with a proportion of naevi and with endothelial cells of small vessels. |
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