| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:20000-1:120000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
MLANA |
| Gene ID: |
2315 |
| Uniprot ID: |
MAR1_HUMAN |
| Immunogen Region: |
11-110 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 11-110 of human Melan-A/MART-1 (NP_005502.1). |
| Immunogen Sequence: |
VLLLIGCWYCRRRNGYRALM DKSLHVGTQCALTRRCPQEG FDHRDSKVSLQEKNCEPVVP NAPPAYEKLSAEQSPPPYSP |
| Tissue Specificity | Expression is restricted to melanoma and melanocyte cell lines and retina. |
| Post Translational Modifications | Acylated. |
| Function | Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes. |
| Protein Name | Melanoma Antigen Recognized By T-Cells 1Mart-1Antigen Lb39-AaAntigen Sk29-AaProtein Melan-A |
| Database Links | Reactome: R-HSA-9824585 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iii Membrane ProteinGolgi ApparatusTrans-Golgi Network MembraneMelanosomeAlso Found In Small Vesicles And Tubules Dispersed Over The Entire CytoplasmA Small Fraction Of The Protein Is Inserted Into The Membrane In An Inverted OrientationInversion Of Membrane Topology Results In The Relocalization Of The Protein From A Predominant Golgi/Post-Golgi Area To The Endoplasmic ReticulumMelanoma Cells Expressing The Protein With An Inverted Membrane Topology Are More Effectively Recognized By Specific Cytolytic T-Lymphocytes Than Those Expressing The Protein In Its Native Membrane Orientation |
| Alternative Antibody Names | Anti-Melanoma Antigen Recognized By T-Cells 1 antibodyAnti-Mart-1 antibodyAnti-Antigen Lb39-Aa antibodyAnti-Antigen Sk29-Aa antibodyAnti-Protein Melan-A antibodyAnti-MLANA antibodyAnti-MART1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
