| Host: | Rabbit |
| Applications: | WB/IHC-P/ICC/IF/IP/FC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit monoclonal anti-MEKK3 for use in WB, IHC-P, ICC, IF, IP and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | R05-5J8 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification: | Affinity Chromatography |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200IP 1:20FC 1:50-1:100 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | MAP3K3 |
| Gene ID: | 4215 |
| Uniprot ID: | M3K3_HUMAN |
| Immunogen: | A synthesized peptide derived from human MEKK3 |
| Post Translational Modifications | Phosphorylation at Ser-166 and Ser-337 by SGK1 inhibits its activity. |
| Function | Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase 3Mapk/Erk Kinase Kinase 3Mek Kinase 3Mekk 3 |
| Database Links | Reactome: R-HSA-9020702 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase 3 antibodyAnti-Mapk/Erk Kinase Kinase 3 antibodyAnti-Mek Kinase 3 antibodyAnti-Mekk 3 antibodyAnti-MAP3K3 antibodyAnti-MAPKKK3 antibodyAnti-MEKK3 antibody |
Information sourced from Uniprot.org