| Tissue Specificity | Expressed in many adult tissues. Abundant in heart and skeletal muscle. |
| Post Translational Modifications | Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases. (Microbial infection) Yersinia YopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway. |
| Function | Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM. |
| Protein Name | Dual Specificity Mitogen-Activated Protein Kinase Kinase 5Map Kinase Kinase 5Mapkk 5Mapk/Erk Kinase 5Mek 5 |
| Database Links | Reactome: R-HSA-198765 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Dual Specificity Mitogen-Activated Protein Kinase Kinase 5 antibodyAnti-Map Kinase Kinase 5 antibodyAnti-Mapkk 5 antibodyAnti-Mapk/Erk Kinase 5 antibodyAnti-Mek 5 antibodyAnti-MAP2K5 antibodyAnti-MEK5 antibodyAnti-MKK5 antibodyAnti-PRKMK5 antibody |
Information sourced from Uniprot.org
