Anti-MEIS2 antibody (Internal) (STJ72247)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-MEIS2 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 50kDa bands observed in Rat Brain and Rat Thymus lysates, 48kDa band in Mouse Brain and 40kDa in Mouse Thymus (calculated MW of 51.8kDa according to Human NP_733775.1 and Mouse |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | MEIS2 |
| Gene ID | 4212 |
| Uniprot ID | MEIS2_HUMAN |
| Accession Number | NP_733777.1; NP_733775.1; NP_758526.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | QSNRAGFLLDPSVSQ |
| Specificity | This antibody is expected to recognize reported Human isoforms a (NP_733777.1) , c (NP_733775.1) , and g (NP_758526.1) , and reported Mouse isoforms 3, 4 and 5 (NP_001153039.1, NP_001153040.1, NP_001153041.1). NB: The immunizing peptide shows no over |
Additional Info
| Function | Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer.the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element.MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'.in cooperation with a PBX protein (such as PBX2) is proposed to be involved in the transcriptional activation of EPHA8 in the developing midbrain. May be involved in regulation of myeloid differentiation. Can bind to the DNA sequence 5'-TGACAG-3'in the activator ACT sequence of the D(1A) dopamine receptor (DRD1) promoter and activate DRD1 transcription.isoform 5 cannot activate DRD1 transcription. |
| Protein Name | Homeobox Protein Meis2Meis1-Related Protein 1 |
| Cellular Localisation | NucleusCytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Homeobox Protein Meis2 antibodyAnti-Meis1-Related Protein 1 antibodyAnti-MEIS2 antibodyAnti-MRG1 antibody |
Information sourced from Uniprot.org