Anti-MEGF10 antibody (26-262) (STJ112531)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MEGF10 (26-262) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MEGF10 |
| Gene ID | 84466 |
| Uniprot ID | MEG10_HUMAN |
| Immunogen Region | 26-262 |
| Immunogen Sequence | ADYTISGTLPHSNGGNANSH YFTNPSYHTLTQCATSPHVN NRDRMTVTKSKNNQLFVNLK NVNPGKRGPVGDCTGTLPAD WKHGGYLNELGAFGLDRSYM GKSLKDLGKNSEYNSSNCSL SSSENPYATIKDPPV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 26-160 of human MEGF10 (NP_115822.1). |
Additional Info
| Tissue Specificity | Expressed in muscle (at protein level). |
| Post Translational Modifications | Phosphorylated on tyrosine residues. Phosphorylation at Tyr-1030 may be important for muscle cell proliferation. Ubiquitinated.mono- and polyubiquitinated forms are detected. |
| Function | Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells. Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides. Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum. Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway. May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements. |
| Protein Name | Multiple Epidermal Growth Factor-Like Domains Protein 10Multiple Egf-Like Domains Protein 10 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell ProjectionPhagocytic CupEnriched At The Sites Of Contact With Apoptotic Thymocyte CellsForms An IrregularMosaic-Like Adhesion Pattern In Region Of The Cell Surface That Becomes Firmely Fixed To The SubstrateExpressed At The Cell Surface In Clusters Around Cell Corpses During EngulfmentDuring The Engulfment Of Apoptotic ThymocytesRecruited At The Bottom Of The Forming Phagocytic CupColocalizes With Abca1 In Absence Of Any Phagocytic ChallengeDoes Not Localize Within LamellipodiaDoes Not Localize With Megf11 |
| Alternative Antibody Names | Anti-Multiple Epidermal Growth Factor-Like Domains Protein 10 antibodyAnti-Multiple Egf-Like Domains Protein 10 antibodyAnti-MEGF10 antibodyAnti-KIAA1780 antibody |
Information sourced from Uniprot.org