| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
MED12 |
| Gene ID: |
9968 |
| Uniprot ID: |
MED12_HUMAN |
| Immunogen Region: |
1800-1900 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 1800-1900 of human MED12 (NP_005111.2). |
| Immunogen Sequence: |
EDYGMGPGRSGPYGVTVPPD LLHHPNPGSITHLNYRQGSI GLYTQNQPLPAGGPRVDPYR PVRLPMQKLPTRPTYPGVLP TTMTGVMGLEPSSYKTSVYR Q |
| Tissue Specificity | Ubiquitous. |
| Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway. |
| Protein Name | Mediator Of Rna Polymerase Ii Transcription Subunit 12Activator-Recruited Cofactor 240 Kda ComponentArc240Cag Repeat Protein 45Mediator Complex Subunit 12Opa-Containing ProteinThyroid Hormone Receptor-Associated Protein Complex 230 Kda ComponentTrap230Trinucleotide Repeat-Containing Gene 11 Protein |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-212436Reactome: R-HSA-381340Reactome: R-HSA-9833110 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Mediator Of Rna Polymerase Ii Transcription Subunit 12 antibodyAnti-Activator-Recruited Cofactor 240 Kda Component antibodyAnti-Arc240 antibodyAnti-Cag Repeat Protein 45 antibodyAnti-Mediator Complex Subunit 12 antibodyAnti-Opa-Containing Protein antibodyAnti-Thyroid Hormone Receptor-Associated Protein Complex 230 Kda Component antibodyAnti-Trap230 antibodyAnti-Trinucleotide Repeat-Containing Gene 11 Protein antibodyAnti-MED12 antibodyAnti-ARC240 antibodyAnti-CAGH45 antibodyAnti-HOPA antibodyAnti-KIAA0192 antibodyAnti-TNRC11 antibodyAnti-TRAP230 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
