Anti-MCRIP1 antibody (14-64 aa) (STJ196193)

Name: Anti-MCRIP1 antibody (14-64 aa) (STJ196193)
SKU: STJ196193
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

ImmunogenSynthesized peptide derived from the human F195B at the amino acid range 14-64

STJ196193

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Short Description	Rabbit polyclonal anti-Mapk-regulated corepressor-interacting protein 1 (14-64 aa) for use in IHC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	IHC/IF
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	1 mg/mL
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Dilution Range	IHC-P 1:50-200 IF 1:50-200
Formulation	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	MCRIP1
Gene ID	348262
Uniprot ID	MCRI1_HUMAN
Immunogen	Synthesized peptide derived from the human F195B at the amino acid range 14-64
Immunogen Region	14-64 aa
Specificity	This antibody detects endogenous levels of F195B at Human/Mouse/Rat

Function	The phosphorylation status of MCRIP1 functions as a molecular switch to regulate epithelial-mesenchymal transition. Unphosphorylated MCRIP1 binds to and inhibits the transcriptional corepressor CTBP(s). When phosphorylated by MAPK/ERK, MCRIP1 releases CTBP(s) resulting in transcriptional silencing of the E-cadherin gene and induction of epithelial-mesenchymal transition.
Protein Name	Mapk-Regulated Corepressor-Interacting Protein 1 Granulin-2 Protein Fam195b
Database Links
Cellular Localisation	Nucleus Cytoplasm Stress Granule
Alternative Antibody Names	Anti-Mapk-Regulated Corepressor-Interacting Protein 1 antibody Anti-Granulin-2 antibody Anti-Protein Fam195b antibody Anti-MCRIP1 antibody Anti-FAM195B antibody Anti-GRAN2 antibody

Information sourced from Uniprot.org