| Host: | Mouse |
| Applications: | WB/IHC/ICC/IF/FC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal anti-MCM6 for use in WB, IHC, ICC, IF and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | 10I9 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3. NA |
| Purification: | Lyophilized |
| Concentration: | Adding 0.2 mL of distilled water =f 500 Mu g/mL. |
| Storage Instruction: | Store at-20°C for up to 1 year. Minimise freeze-thaw cycles. |
| Gene Symbol: | MCM6 |
| Gene ID: | 4175 |
| Uniprot ID: | MCM6_HUMAN |
| Immunogen: | E.coli-derived human MCM6 recombinant protein (Position: Q14-D821). |
| Function | Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity. |
| Protein Name | Dna Replication Licensing Factor Mcm6P105mcm |
| Database Links | Reactome: R-HSA-176187Reactome: R-HSA-176974Reactome: R-HSA-68867Reactome: R-HSA-68949Reactome: R-HSA-68962Reactome: R-HSA-69052 |
| Cellular Localisation | NucleusChromosomeBinds To Chromatin During G1 And Detaches From It During S Phase |
| Alternative Antibody Names | Anti-Dna Replication Licensing Factor Mcm6 antibodyAnti-P105mcm antibodyAnti-MCM6 antibody |
Information sourced from Uniprot.org