| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-MCL1 (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx 35kDa band observed in lysates of Human Lung (calculated MW of 37.3kDa according to NP_068779.1). Recommended concentration: 1-3µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | MCL1 |
| Gene ID: | 4170 |
| Uniprot ID: | MCL1_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_068779.1; NP_001184249.1 |
| Specificity: | This antibody is expected to recognise reported isoform 1 (NP_068779.1) and isoform 3 (NP_001184249.1). |
| Immunogen Sequence: | AGVGAGLAYLIR |
| Function | Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis. |
| Protein Name | Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1Bcl-2-Like Protein 3Bcl2-L-3Bcl-2-Related Protein Eat/Mcl1Mcl1/Eat |
| Database Links | Reactome: R-HSA-6785807Reactome: R-HSA-9725370 |
| Cellular Localisation | MembraneSingle-Pass Membrane ProteinCytoplasmMitochondrionNucleusNucleoplasmCytoplasmicAssociated With Mitochondria |
| Alternative Antibody Names | Anti-Induced Myeloid Leukemia Cell Differentiation Protein Mcl-1 antibodyAnti-Bcl-2-Like Protein 3 antibodyAnti-Bcl2-L-3 antibodyAnti-Bcl-2-Related Protein Eat/Mcl1 antibodyAnti-Mcl1/Eat antibodyAnti-MCL1 antibodyAnti-BCL2L3 antibody |
Information sourced from Uniprot.org