| Host: |
Rabbit |
| Applications: |
WB/IP/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Membrane-bound transcription factor site-2 protease (301-350 aa) is suitable for use in Western Blot, Immunoprecipitation, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IF 1:200-1:1000ELISA 1:20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
MBTPS2 |
| Gene ID: |
51360 |
| Uniprot ID: |
MBTP2_HUMAN |
| Immunogen Region: |
301-350 aa |
| Specificity: |
S2P Polyclonal Antibody detects endogenous levels of S2P protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human MBTPS2 at the amino acid range 301-350 |
| Function | Zinc metalloprotease that mediates intramembrane proteolysis of proteins such as ATF6, ATF6B, SREBF1/SREBP1 and SREBF2/SREBP2. Catalyzes the second step in the proteolytic activation of the sterol regulatory element-binding proteins (SREBPs) SREBF1/SREBP1 and SREBF2/SREBP2: cleaves SREBPs within the first transmembrane segment, thereby releasing the N-terminal segment with a portion of the transmembrane segment attached. Mature N-terminal SREBP fragments shuttle to the nucleus and activate gene transcription. Also mediates the second step in the proteolytic activation of the cyclic AMP-dependent transcription factor ATF-6 (ATF6 and ATF6B). Involved in intramembrane proteolysis during bone formation. In astrocytes and osteoblasts, upon DNA damage and ER stress, mediates the second step of the regulated intramembrane proteolytic activation of the transcription factor CREB3L1, leading to the inhibition of cell-cycle progression. |
| Protein Name | Membrane-Bound Transcription Factor Site-2 ProteaseEndopeptidase S2pSterol Regulatory Element-Binding Proteins Intramembrane ProteaseSrebps Intramembrane Protease |
| Database Links | Reactome: R-HSA-1655829Reactome: R-HSA-381033Reactome: R-HSA-8874177Reactome: R-HSA-8874211Reactome: R-HSA-8963889 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCytoplasmGolgi Apparatus Membrane |
| Alternative Antibody Names | Anti-Membrane-Bound Transcription Factor Site-2 Protease antibodyAnti-Endopeptidase S2p antibodyAnti-Sterol Regulatory Element-Binding Proteins Intramembrane Protease antibodyAnti-Srebps Intramembrane Protease antibodyAnti-MBTPS2 antibodyAnti-S2P antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
