| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Rat/Mouse/Marmoset |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Mature-BDNF (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:1000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
BDNF |
| Gene ID: |
627 |
| Uniprot ID: |
BDNF_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
Specific for mature BDNF. |
| Immunogen: |
A synthetic peptide from c-terminal region of mature mouse BDNF conjugated to blue carrier protein was used as the antigen. |
| Post Translational Modifications | Neurotrophic factor BDNF precursor form: N-glycosylated and glycosulfated, contrary to mature BDNF. Mature BDNF is produced by proteolytic removal of the propeptide, catalyzed by a FURIN family member. In addition, the precursor form is proteolytically cleaved within the propeptide, but this is not an obligatory intermediate for the production of mature BDNF. Can be converted into mature BDNF by plasmin (PLG). |
| Function | Important signaling molecule that activates signaling cascades downstream of NTRK2. During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. Neurotrophic factor BDNF precursor form: Important signaling molecule that activates signaling cascades downstream of NTRK2. Activates signaling cascades via the heterodimeric receptor formed by NGFR and SORCS2. Signaling via NGFR and SORCS2 plays a role in synaptic plasticity and long-term depression (LTD). Binding to NGFR and SORCS2 promotes neuronal apoptosis. Promotes neuronal growth cone collapse. |
| Protein Name | Neurotrophic Factor Bdnf Precursor FormProbdnfAbrineurinBrain-Derived Neurotrophic Factor Cleaved Into - Neurotrophic Factor Bdnf |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-6811558Reactome: R-HSA-9022702Reactome: R-HSA-9024909Reactome: R-HSA-9026519Reactome: R-HSA-9026527Reactome: R-HSA-9028335Reactome: R-HSA-9028731Reactome: R-HSA-9032500Reactome: R-HSA-9032759Reactome: R-HSA-9032845Reactome: R-HSA-9768919 |
| Cellular Localisation | SecretedNeurotrophic Factor Bdnf Precursor Form: SecretedA Proportion Of Bdnf Is Secreted As Immature Precursor (Probdnf) |
| Alternative Antibody Names | Anti-Neurotrophic Factor Bdnf Precursor Form antibodyAnti-Probdnf antibodyAnti-Abrineurin antibodyAnti-Brain-Derived Neurotrophic Factor Cleaved Into - Neurotrophic Factor Bdnf antibodyAnti-BDNF antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
