| Short Description : | Mouse monoclonal anti-Cartilage matrix protein for use in WB, IF and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ELISA |
| Host: | Mouse |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | 5A8 |
| Isotype: | IgG1 |
| Conjugation: | Unconjugated |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000 |
| Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MATN1 |
| Gene ID: | 4146 |
| Uniprot ID: | MATN1_HUMAN |
| Immunogen: | Purified recombinant fragment of human Matrilin-1 expressed in E. Coli. |
| Specificity: | Matrilin-1 Monoclonal Antibody detects endogenous levels of Matrilin-1 protein. |
| Function | A major component of the extracellular matrix of non-articular cartilage. Binds to type 2 collagens and forms long concatenated protein networks as part of the extracellular matrix. Required for the network-like organization and bundling of collagen fibrils surrounding chondrocytes in the zones of maturation and hypertrophy. Required for mechanotransduction and adaption to mechanical loading in cartilage chondrocytes, resulting in an increase in expression of the extracellular matrix components ACAN and COL2A1. Acts as a moderator of angiogenesis in response to injury. |
| Protein Name | Matrilin-1Cartilage Matrix Protein |
| Database Links | Reactome: R-HSA-3000178 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Matrilin-1 antibodyAnti-Cartilage Matrix Protein antibodyAnti-MATN1 antibodyAnti-CMP antibodyAnti-CRTM antibody |
Information sourced from Uniprot.org
