| Host: | Mouse |
| Applications: | WB/IF/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Cartilage matrix protein is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 5A8 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MATN1 |
| Gene ID: | 4146 |
| Uniprot ID: | MATN1_HUMAN |
| Specificity: | Matrilin-1 Monoclonal Antibody detects endogenous levels of Matrilin-1 protein. |
| Immunogen: | Purified recombinant fragment of human Matrilin-1 expressed in E. Coli. |
| Function | A major component of the extracellular matrix of non-articular cartilage. Binds to type 2 collagens and forms long concatenated protein networks as part of the extracellular matrix. Required for the network-like organization and bundling of collagen fibrils surrounding chondrocytes in the zones of maturation and hypertrophy. Required for mechanotransduction and adaption to mechanical loading in cartilage chondrocytes, resulting in an increase in expression of the extracellular matrix components ACAN and COL2A1. Acts as a moderator of angiogenesis in response to injury. |
| Protein Name | Matrilin-1Cartilage Matrix Protein |
| Database Links | Reactome: R-HSA-3000178 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Matrilin-1 antibodyAnti-Cartilage Matrix Protein antibodyAnti-MATN1 antibodyAnti-CMP antibodyAnti-CRTM antibody |
Information sourced from Uniprot.org
