Anti-MARCKSL1 antibody (1-80 aa) (STJ190198)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 1-80
General Information
| Short Description | Rabbit polyclonal anti-MARCKS-related protein (1-80 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MARCKSL1 |
| Gene ID | 65108 |
| Uniprot ID | MRP_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 1-80 |
| Immunogen Region | 1-80 aa |
| Specificity | MRP Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. |
| Protein Name | Marcks-Related ProteinMarcks-Like Protein 1Macrophage Myristoylated Alanine-Rich C Kinase SubstrateMac-MarcksMacmarcks |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell MembraneLipid-AnchorAssociates With The Membrane Via The Insertion Of The N-Terminal N-Myristoyl Chain And The Partial Insertion Of The Effector DomainAssociation Of The Effector Domain With Membranes May Be Regulated By Ca(2+)/CalmodulinColocalizes With F-Actin At The Leading Edge Of Migrating CellsIn Prostate CancersShows Strong Expression At Apical And/Or Basal Regions Of The Cell And Also Has Weak Cytoplasmic Expression |
| Alternative Antibody Names | Anti-Marcks-Related Protein antibodyAnti-Marcks-Like Protein 1 antibodyAnti-Macrophage Myristoylated Alanine-Rich C Kinase Substrate antibodyAnti-Mac-Marcks antibodyAnti-Macmarcks antibodyAnti-MARCKSL1 antibodyAnti-MLP antibodyAnti-MRP antibody |
Information sourced from Uniprot.org