| Function | Controls cell movement by regulating actin cytoskeleton homeostasis and filopodium and lamellipodium formation. When unphosphorylated, induces cell migration. When phosphorylated by MAPK8, induces actin bundles formation and stabilization, thereby reducing actin plasticity, hence restricting cell movement, including neuronal migration. May be involved in coupling the protein kinase C and calmodulin signal transduction systems. |
| Protein Name | Marcks-Related ProteinMarcks-Like Protein 1Macrophage Myristoylated Alanine-Rich C Kinase SubstrateMac-MarcksMacmarcks |
| Cellular Localisation | CytoplasmCytoskeletonCell MembraneLipid-AnchorAssociates With The Membrane Via The Insertion Of The N-Terminal N-Myristoyl Chain And The Partial Insertion Of The Effector DomainAssociation Of The Effector Domain With Membranes May Be Regulated By Ca(2+)/CalmodulinColocalizes With F-Actin At The Leading Edge Of Migrating CellsIn Prostate CancersShows Strong Expression At Apical And/Or Basal Regions Of The Cell And Also Has Weak Cytoplasmic Expression |
| Alternative Antibody Names | Anti-Marcks-Related Protein antibodyAnti-Marcks-Like Protein 1 antibodyAnti-Macrophage Myristoylated Alanine-Rich C Kinase Substrate antibodyAnti-Mac-Marcks antibodyAnti-Macmarcks antibodyAnti-MARCKSL1 antibodyAnti-MLP antibodyAnti-MRP antibody |
Information sourced from Uniprot.org
