| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
SRM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
MARCHF5 |
| Gene ID: |
54708 |
| Uniprot ID: |
MARH5_HUMAN |
| Immunogen Region: |
179-278 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 179-278 of human MARCH5 (NP_060294.1). |
| Immunogen Sequence: |
LNSIFPGIGCPVPRIPAEAN PLADHVSATRILCGALVFPT IATIVGKLMFSSVNSNLQRT ILGGIAFVAIKGAFKVYFKQ QQYLRQAHRKILNYPEQEEA |
| Tissue Specificity | Expressed in brain, heart, liver, lung, spleen, stomach, testis, skeletal and muscle. |
| Post Translational Modifications | Autoubiquitinated leading to degradation (short half-life). |
| Function | Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Marchf5Membrane-Associated Ring Finger Protein 5Membrane-Associated Ring-Ch Protein VMarch-VMitochondrial Ubiquitin LigaseMitolRing Finger Protein 153Ring-Type E3 Ubiquitin Transferase Marchf5 |
| Cellular Localisation | Mitochondrion Outer MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum MembraneAuthors Show That The Protein Can Be Detected In Endoplasmic ReticulumAuthors Show Its Presence Only In Mitochondria |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Marchf5 antibodyAnti-Membrane-Associated Ring Finger Protein 5 antibodyAnti-Membrane-Associated Ring-Ch Protein V antibodyAnti-March-V antibodyAnti-Mitochondrial Ubiquitin Ligase antibodyAnti-Mitol antibodyAnti-Ring Finger Protein 153 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Marchf5 antibodyAnti-MARCHF5 antibodyAnti-MARCH5 antibodyAnti-RNF153 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
